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KMID : 0363320080290030641
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 3 p.641 ~ p.656
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Effects of Gamichungyeoldodam-tang(GCDT) in DOCA-saIt Induced Hypertensive Rats
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Baek Hye-ki
An Joung-Jo
Cho Hyun-Kyoung
Yoo Ho-Rhyong
Kim Yoon-Sik
Seol In-Chan
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Abstract
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This study was done to investigate the effect of Gamichungyeoldodam-tang (GCDT) in DOCA-salt induced hypertensive rats. The results were obtained as follows : GCDT showed safety against cytotoxicity and toxicity in the liver and the kidney. GCDT showed an inhibitory effect on ACE. GCDT significantly decreased the heart rate and the blood pressure in DOCA-salt induced hypertensive rats. GCDT significantly decreased the levels of aldosterone in DOCA-salt induced hypertensive rats. GCDT significantly decreased the levels of dopamine, norepinephrine, and epinephrine in DOCA-salt induced hypertensive rats. GCDT significantly decreased the levels of chloride in DOCA-salt induced hypertensive rats. These results suggest that GCDT might be effective in treatment of hypertension.
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KEYWORD
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Gamichungyeoldodam-tang(GCDT), Hypertension, DOCA-salt, ACE
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